Isoform 2 of INPP5F (INPP5F_V2; inositol polyphosphate-5-phosphatase F, isoform 2) was exclusively
expressed from the
paternal allele in fetal brain, heart and tongue in one
informative fetus, and monoallelically expressed in two additional fetuses (same tissues). Its
promoter shows germline maternal methylation (Wood
AJ et al, 2007). Mouse Inpp5f_v2 is also imprinted and paternally
INPP5F_V2 is a retrogene derived from the X chromosome gene TMEM114A. Isoform 2 probably does not
encode a protein.
INPP5F_V2 is present in all eutherian mammals but is absent from the opossum genome.
Morcos L et al (2011) found no evidence of
allelic expression bias in lymphoblast and fibroblast cell lines.