Taxon:

Cow

Gene:

GNAS complex locus (GNAS, NESP55, GNASXL)

Chromosome:

13

Location:

58.0 Mb (Bos_taurus_UMD_3.1 Primary Assembly)

Description:

Bovine Nesp55 (neuroendocrine secretory protein) within the GNAS1 complex is maternally expressed (Khatib H 2004). Maternally derived monoallelic transcripts were detected in several tissues from four fetuses and one dam.
GNAS was maternally expressed in four day 105 B. t. indicus x B. t. taurus hybrid conceptus tissues (brain, kidney, liver, skeletal muscle and placenta). Methylation status of GNAS was confirmed by bisulfite conversion followed by cloning and Sanger sequencing. The maternal allele was hypomethylated and the paternal allele was hypermethylated, consistent with maternal expression of this gene (Chen Z et al 2016).

GNASXL, located in the GNAS/GNASXL domain, is a paternally expressed transcript isoform that has a unique first exon and shares the rest of its sequence with the maternally expressed GNAS (NESP55). This parent-of-origin specific expression was validated by using 2 SNPs (one specific to GNAS and one specific to GNASXL).
GNASXL was paternally expressed in four day 105 B. t. indicus x B. t. taurus hybrid conceptus tissues (brain, kidney, liver, skeletal muscle and placenta). Methylation status of GNASXL was confirmed by bisulfite conversion followed by cloning and Sanger sequencing. The paternal allele was hypomethylated and the maternal allele was hypermethylated, consistent with paternal expression of this gene (Chen Z et al 2016).

Category:

Imprinted genes

Record:

1066

Last Modified 3/9/2017

Links:

Gene  


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