13 families with thrombosis and high factor VIII levels (FVIII-R) were analysed by a genome scan
using 402 microsattelite markers. A single-trait-locus MOD-score analysis showed suggestive for
linkage under an imprinting model at chromosomes 5 and 11. A 2-trait-locus, multiplicative model for
paternal linkage of the loci on chromsomes 5 and 11 yielded a LOD score of 4.44 (Berger
M et al, 2005).