Taxon:

Human

Gene:

CTNNA3

Chromosome:

10

Location:

10q21.3

Description:

CTNNA3 (catenin (cadherin-associated protein), alpha 3) was reported to show polymorphic imprinting. It showed monoallelic expression in ONE of three placental samples (8-12 weeks gestation); the other two showed equal biallelic expression. Immunostaining of a partial hydatidiform mole showed absence of expression in villous trophoblast of villi with hydropic changes (the presumed androgenetic villi), whereas expression was detected in non-hydropic villi of normal origin (van Dijk M et al, 2004). CTNNA3 was studied since it was a candidate for the parent-of-origin effect in familial pre-eclampsia, but subsequent studies have excluded CTNNA3 from the minimal critical region (van Dijk M et al, 2005).
Meehan M et al (2007) reported biallelic expression in normal urothelial samples.
In mice, allele-specific expression studies showed biallelic expression in mouse fetal and placental tissues (Inglesias-Platas I et al, 2007).
In view of negative reports, the evidence from a single sample is no longer sufficient to sustain a claim of polymorphic imprinting (IMM - comment).

Category:

Other

Record:

638

Last Modified 4/4/2008

Links:

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