Taxon:

Human

Gene:

pre-eclampsia susceptibility

Chromosome:

10

Location:

10q22

Description:

Sib-pair analysis of 24 families with pre-eclampsia indicated linkage to 10q22.1, with haplotype analysis revealing maximum allele sharing between affected siblings for maternally derived alleles only. A region between markers GATA121A08 and D10S580 was screened in silico for common imprinting hallmarks, which directed the search for down-regulated transcripts in androgenetic placentas. Two clusters near markers CTNNA3 and KCNMAI each contained five genes with down-regulated expression in androgenic placentas, consistent with the regions demonstrating maximal maternal allele sharing (Oudejans CB et al, 2004).

Category:

Parental effect

Record:

606

Last Modified 2/27/2007

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