Sib-pair analysis of 24 families with pre-eclampsia indicated linkage to 10q22.1, with haplotype
analysis revealing maximum allele sharing between affected siblings for maternally derived alleles
only. A region between markers GATA121A08 and D10S580 was screened in silico for common
imprinting hallmarks, which directed the search for down-regulated transcripts in androgenetic
placentas. Two clusters near markers CTNNA3 and KCNMAI each contained five genes with down-regulated
expression in androgenic placentas, consistent with the regions demonstrating maximal maternal
allele sharing (Oudejans
CB et al, 2004).