A study from a sample of 148 sibships with late onset AD found maternal linkage to a region on
chromosome 10 with a maximum Z-score of 3.88 (LOD = 3.27) at D10S1220 (Bassett
et al. 2002).
The maternal effect was confirmed in an independent set of pedigrees (Bassett
SS et al, 2006).
ASAH2B (ASAH2L) has been proposed as a candidate gene (Avramopoulos
D et al, 2007).