Taxon:

Human

Gene:

Alzheimer disease

Chromosome:

10

Location:

10q11-21; 65-80 cM

Description:

A study from a sample of 148 sibships with late onset AD found maternal linkage to a region on chromosome 10 with a maximum Z-score of 3.88 (LOD = 3.27) at D10S1220 (Bassett et al. 2002).
The maternal effect was confirmed in an independent set of pedigrees (Bassett SS et al, 2006).
ASAH2B (ASAH2L) has been proposed as a candidate gene (Avramopoulos D et al, 2007).

Category:

Parental effect

Record:

486

Last Modified 1/13/2014

Links:

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