Taxon:

Human

Gene:

Oligodendrogliomas

Chromosome:

19

Location:

19q

Description:

Portions of 19q are frequently deleted in oligodendrogliomas. There is evidence that some loci on 19q are imprinted and hence putative tumour suppressor genes in this region may be monoallelically expressed. In one study 100% of deletions were paternal (6/6) suggesting they were preferentially lost (Sanson M et al. 2002). However a subsequent study showed only 40% of deletions were paternal (4/10) demonstrating no preferential loss of 19q (Hartmann C et al. 2003). A further study by Sanson's group confirmed findings by Hartmann et al, with 15 more parental losses showing a random distribution. RT-PCR analysis of the paternally expressed 19q gene PEG3, showed low expression in tumours losing paternal 19q, compared to those with maternal loss of 19q and intact tumours, demonstrating that imprinting was being maintained in these cells (Trouillard O et al,2004).

Category:

Parental effect

Record:

469

Last Modified 28/01/2005

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