A panel of families with children with atopic dermatitis (338 children total) was analysed by
transmission disequilibrium for inheritance of common polymorphisms of SPINK5. Asn368 and Lys420
were shown to be significantly associated (P = 0.005 and P = 0.023) with an increased risk of atopy
when maternally inherited. These alleles were further investigated in a second panel (215 offspring)
which showed significant association of the maternally derived Lys420 allele with atopy, atopic
dermatitis, asthma and total serum IgE (P = 0.008, 0.002, 0.012, 0.040) (Walley
AJ et al, 2001).
Polymorphisms in the SPINK5 (serine protease inhibitor, kazal-type; 5) gene have been associated
with atopic dermatitis in a Japanese population and inheritance is preferentially maternal (Nishio
Y et al. 2003).