Rtl1, similar to its paralogue Peg10 on mouse chromosome 6, is a
retrotransposon derived gene with open reading frames
showing homology to viral gag and pol proteins. Rtl1 is exclusively paternally expressed (Seitz H et al. 2003).
Other paternally expressed genes in this region include Dlk1 and Dio3. Rtl1 also lies next to other maternally
expressed non-coding RNAs such as a C/D
snoRNA cluster of at least nine snoRNAs (see Rian) (Cavaillé J et al. 2002), as well as
another cluster of miRNAs (see Mirg) and Meg3.
of imprinted genes is conserved with human 14q32.