Taxon:

Mouse

Gene:

Mkrn1-ps1 (Makorin1-ps1) (refuted)

Chromosome:

05

Location:

48.0 cM, 5 E1

Description:

Mkrn1-ps1 (Mkrn-p1) is a pseudogene homologous to the 5 end of Mkrn1 (makorin ring finger protein 1, chromosome 6). Although Mkrn1-ps1 was reported to be preferentially paternally expressed (Hirotsune S, et al. 2003) the expression and imprinting of Mkrn1-ps1 has been firmly refuted (Gray TA et al, 2006).
A transgene insertion into Mkrn1-ps1 was shown to cause reduced life span, reduced bone density, bone deformities, renal polycystic dilation and early opening eyes. This phenotype was observed when the transgene was inherited paternally (99/108), but only rarely when inherited maternally (3/96)(Hirotsune S, et al. 2003).

Category:

Other

Record:

440

Last Modified 8/7/2006

Links:

Gene  


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