Taxon:

Human

Gene:

Bipolar affective disorder

Chromosome:

General

Location:

Description:

Several reports have suggested various parent-of-origin effects for the inheritance of bipolar affective disorder (BPAD) susceptibility. For example, cases with paternal transmission showed earlier onset, and anticipation was found only with paternal inheritance. This effect may be attributable to trinucleotide repeat expansions (O'Donovan MC et al. 1995; Oruc L et al. 1997; Grigoroiu-Serbanescu M et al. 1993; Grigoroiu-Serbanescu M et al. 1995; Grigoroiu-Serbanescu M et al. 1997; McMahon FJ et al. 1995; Stine OC et al. 1995; McMahon FJ et al. 1997; Nothen MM et al. 1999). The presence of parental effects has been disputed by others (Kato T et al. 1996; Ohara K et al. 1998). In an evaluation of the parent-of-origin effect in BPAD, a large sample of families was used to assess transmission rates to offspring from affected parents. The rate of BPAD among the offspring of affected fathers was significantly higher than that for affected mothers (X2 = 4.3, P = 0.04). This result suggests a possible paternal parent of origin effect for BPAD (Kornberg JR, et al. 2000). This inheritance pattern has also been suggested to reflect a mtDNA polymorphism (5178C) with a phenotype related to brain energy metabolism (Kato T, et al. 2000).

Category:

Parental effect

Record:

438

Last Modified 6/18/2007

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