Taxon:

Human

Gene:

OSBPL5 (OBPH1)

Chromosome:

11

Location:

11p15.5 (12)

Description:

OSBPL5 (Oxysterol binding protein-like 5, OBPH1) shows predominant maternal expression in the placenta but biallelic expression in fetal and newborn organs. These results suggest that the 11p15 imprinted region extends to OSBPL5. Identical results were achieved in mouse samples (Higashimoto K, et al. 2002)
Okae H et al, (2012) found no evidence of imprinting of OSBPL5 in the placenta and trophoblast stem cells (TS)in mouse studies. This is concordant with Proudhon and Bourc'his, (2010) caution that maternal contamination of placental tissues may cause apparent imprinted maternal expression.
Morcos L et al, (2011) found no evidence of allelic expression bias in fibroblast cell lines.

Category:

Other

Record:

428

Last Modified 7/15/2012

Links:

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