Taxon:

Human

Gene:

WT1 (AWT1, WT1 alternative)

Chromosome:

11

Location:

11p13

Description:

An alternative transcript of WT1 (Wilms tumour 1), AWT1, is reported to be paternally expressed in kidney, together with the WT1 antisense transcript. Although monoallelic expression was clearly demonstrated, paternal expression was only demonstrated in one normal kidney sample, and was inferred from continued expression in two Wilms tumours with loss of heterozygosity and retention of the paternal allele (Dallosso AR et al, 2004).
WT1 was previously reported to be partially or completely imprinted and maternally expressed in 5 of 9 preterm placentas and in 2 fetal brains (Jinno Y et al, 1994), and in 7 of 19 placental villus samples from gestational age 4 to 21 weeks (Nishiwaki K et al, 1997) but was paternally expressed in fibroblasts and lymphocytes from two of seven individuals (Mitsuya K et al, 1997).
In contrast equal expression of WT1 alleles has been reported for fetal kidney (Little MH et al, 1992). Biallelic expression of WT1 was detected in 6/6 human embryonic cell lines (Kim KP et al, 2007).
De novo germ line deletions of WT1 preferentially (7/8) occur during male gametogenesis - this not regarded as an imprinting effect (Huff V et al, 1990).
See also WT1-AS.

Category:

Imprinted genes

Record:

35

Last Modified 1/26/2016

Links:

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