Gatm (L-arigine:glycine amidinotransferase) RT-PCR studies of Gatm (L-arigine:glycine
amidinotransferase) showed exclusive maternal expression in the placenta and
predominant maternal expression in the yolk sac, whereas biallelic expression was observed in
embryonic kidney, brain and gonadal tissues. Genes located near Gatm show no evidence of imprinting
and both Gatm and a neighbouring gene are associated with unmethylated CpG islands (Sandell
LL et al, 2003).
However, Okae H et al, (2012) found no
evidence of imprinting of Gatm in the placenta, and the apparent imprinting was attributed to high
expression of this gene in maternal decidua.
Human and pig GATM are reported to be not imprinted.