Taxon:

Human

Gene:

DDC

Chromosome:

07

Location:

7p12.2, 50.6 Mb

Description:

DDC (dopa decarboxylase) lies 27 kb from GRB10, an imprinted gene implicated in Silver-Russell syndrome. In an association study between bipolar affective disorder and a DDC allele with a 4 bp deletion polymorphism (in a neuronally untranslated exon), 100 case-parent trios indicated preferential paternal transmission (P = 0.006), suggesting a parent of origin effect (Borglum AD et al, 2003). Previous studies have shown that although there is evidence of asynchronous replication of DDC, expression analysis shows biallelic expression of DDC in various human (brain, eye, tongue, gut, kidney, liver, lung, skin, placenta) and mouse (brain, liver, kidney) tissues (Hitchins MP et al, 2002).
Imprinting of the exon 1a transcript of mouse Ddc has now been documented in mouse heart (Menheniott TR et al, 2007).

Category:

Parental effect

Record:

407

Last Modified 1/25/2016

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