Taxon:

Mouse

Gene:

Rian (Meg8; C/D snoRNA cluster: MBII-343, MBII-426, MBII-78, MBII-19, MBII-48, MBII-49, mir370, mir1188, mir341)

Chromosome:

12

Location:

54.5 cM (1), 107.1 Mb (Feb 06)

Description:

Rian (RNA Imprinted and Accumulated in the Nucleus, Meg8; C/D snoRNA cluster) was first identified by maternally expressed transcripts detected only in the brain, predominantly localised in the nucleus (Hatada I et al. 2001). Rian encodes or is close to a cluster of at least 9 C/D small nucleolar RNAs (C/D snoRNAs) including MBII-343, MBII-426, MBII-78, MBII19, MBII-48 and MBII-49 that are all imprinted and maternally expressed (Cavaille J et al, 2002; Shimoda M et al, 2002) and a microRNAs, mir370, mir1188 and mir341 (Seitz H et al. 2004).
Rian lies within a cluster of imprinted genes including maternally expressed non-coding transcripts such as Mirg and Gtl2 as well as paternally expressed genes Dlk1 and Dio3. This region, including the C/D snoRNAs, is conserved with Human 14q32.
Note: this entry needs more detailed annotation to describe the relationship of the miRNAs and snoRNA to Rian.

Category:

Imprinted genes

Record:

286

Last Modified 2/8/2016

Links:

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