Taxon:

Sheep

Gene:

DLK1

Chromosome:

18

Location:

18q (IDVGA30-OY3)

Description:

Ovine DLK1 (Delta-like 1, a member of the EGF-like homeotic protein family) is one of 6 imprinted transcripts within a 250 kb region of chromosome 18q. DLK1 was paternally expressed as it is in human and mouse (Charlier C et al 2001).
The sheep Callipyge mutation is mediated through overexpression of DLK1, but only when the mutation is paternally inherited and the maternal allele is wildtype (Charlier C et al 2001). A mouse knockout of the miR-379/miR-544 cluster suggests that miRNA expression from this cluster regulates DLK1 (Gao YQ et al, 2015).

Category:

Imprinted genes

Record:

280

Last Modified 1/16/2017

Links:

Gene  


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