Ovine DLK1 (Delta-like 1, a member of the EGF-like homeotic protein family) is one of 6 imprinted
transcripts within a 250 kb region of chromosome 18q. DLK1 was paternally expressed as it is in
human and mouse (Charlier
C et al 2001).
The sheep Callipyge mutation is mediated through overexpression of DLK1, but only when the mutation
is paternally inherited and the maternal allele is wildtype (Charlier
C et al 2001). A mouse knockout of the miR-379/miR-544 cluster suggests that miRNA expression
from this cluster regulates DLK1 (Gao YQ et