Taxon:

Mouse

Gene:

Airn (Air, Igf2rAS)

Chromosome:

17

Location:

07.36 cM, proximal

Description:

Igf2r has a paternally expressed antisense non-coding RNA transcript (Airn, Igf2rAS, Air (Antisense Igf2r RNA)) that arises in intron 2 of Igf2r (Wutz A et al, 1997; Hu JF et al, 1999 ; Lyle R et al, 2000 ; Alenina N et al, 2002 ). The Airn transcript silences Igf2r and adjacent genes Slc22a2 and Slc22a3 in cis (Sleutels F et al 2003; Seidl C et al, 2006). Airn silences Igf2r by transcriptional overlap of the Igf2r promoter (Latos PA et al, 2012).
Imprinting of Slc22a3 involves accumulation of Airn at the Slc22a3 promoter together with the recruitment of H3K9 histone methyltransferase G9a (Nagano T et al, 2008).

Category:

Imprinted genes

Record:

274

Last Modified 12/16/2012

Links:

Gene  


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