Taxon:

Mouse

Gene:

Kcnq1ot1 (Kvlqt-as)

Chromosome:

07

Location:

69.3 cM (6), distal

Description:

Kcnq1ot1 (KCNQ1 overlapping transcript 1, Kvlqt-as) is an antisense transcript of Kcnq1. It is paternally expressed in day 9.5. 10.5 and 17.5 placentas and embryos (Fitzpatrick GV et al, 2002; Umlauf D et al, 2004; Lewis A et al, 2004; Higgins MJ, Am J Hum Genet 1998;63(4 Suppl):A328).
Kcnq1ot1 expression is under the control of a differentially methylated imprint control region, KvDMR1. Expression of Kcnq1ot1 from the unmethylated paternal allele regulates imprinted expression by silencing genes on the paternal chromosome (Fitzpatrick GV et al, 2002).
Mechanisms by which Kcnq1ot1 represses the other imprinted genes in the domain are explored by Lewis A et al (2004), Umlauf D et al (2004), Green K et al (2007) and Shin JY et al (2007).

Category:

Imprinted genes

Record:

273

Last Modified 11/9/2011

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