Taxon:

Cow

Gene:

IGF2R

Chromosome:

09

Location:

59 Mb (Mar 2005 assembly)

Description:

IGF2R (insulin-like growth factor 2 receptor) is monoallelically expressed in fetal cows (the number of animals studied was not reported) and was assumed to be imprinted (Killian JK et al, 2001).
Predominantly maternal expression in all fetal tissues except brain was demonstrated by Bebbere D et al (2013).
DMR analysis of the gene showed 4% methylation in sperm and 46.9% methylation in liver consistent with imprinting of the gene and maternal silencing. Bisulphite clones harbouring both fully methylated and fully unmethylated sequences were present for IGR2R (O'Doherty AM et al, 2011).

Category:

Imprinted genes

Record:

263

Last Modified 1/26/2016

Links:

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