Taxon:

Mouse

Gene:

"LOH in lung cancer"

Chromosome:

04

Location:

42.6-55.6 cM

Description:

Mice with spontaneous and methylene chloride-induced lung carcinomas showed preferential loss of the maternally derived chromosome 4 (ratio of lost maternal:paternal alleles=10:2 in spontaneous tumours and 21:5 in chemically induced tumours). The region of loss is distal to Ifa2 and proximal to D4Nds2 (Hegi ME et al, 1994).

Category:

Parental effect

Record:

262

Last Modified 4/28/2010

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