Taxon:

Mouse

Gene:

"LOH in mouse leukaemia"

Chromosome:

04

Location:

14.5-17.9 cM

Description:

In radiation-induced murine acute myeloid leukaemia and early B lympho-myeloid leukaemias, there was preferential loss of heterozygosity of the maternal allele (25/28 cases). LOH involved a region between 14.5 and 17.9 cM on chromosome 4. The maternal effect did not appear to be attributable to a genetic (strain) effect (Cleary H et al, 2001).

Category:

Parental effect

Record:

261

Last Modified 4/28/2010

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