Taxon:

Sheep

Gene:

IGF2R (M6PR)

Chromosome:

08

Location:

Description:

IGF2R (M6PR) is maternally expressed in sheep (Killian JK et al, 2001; Thurston A et al 2008). The second intron differentially methylated region (DMR2) in IGF2R in sheep shows differential methylation (suggestive of imprinting). Hypomethylation of DMR2 (in mice, hypomethylation is associated with loss of IGF2R expression) was associated with "large offspring syndrome" (Young LE et al, 2001).

Category:

Imprinted genes

Record:

255

Last Modified 1/4/2008

Links:

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