Taxon:

Mouse

Gene:

Atp10a (Atp10c, Pfatp)

Chromosome:

07

Location:

29 cM approx

Description:

Atp10a (ATPase, class V, type 10A) was reported to be predominantly expressed from the maternal allele in the hippocampus and olfactory bulb in C57BL/6J x JF1 F1 hybrid mice (Kashiwagi A et al, 2003). However, others have reported that Atp10a is biallelically expressed in multiple tissues including brain in PWK x C57BL/6J hybrids (Kayashima T et al, 2003a). Kayashima et al suggest that imprinting may be strain-background dependent (Kayashima T et al, 2003b)
Mice heterozygous for maternally inherited deletions of the Plo1 locus (p-locus-associated obesity) have nearly double the body fat of mice who inherit a paternal deletion. Plo1 is between Gabrb3 and Ube3a. Atp10a is a candidate gene for the increased body fat (Dhar M et al 2000).
Okae H et al, (2012) confrimed bialleic expression of Atp10a in placenta.

Category:

Other

Record:

254

Last Modified 2/4/2013

Links:

: Gene  


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