Taxon:

Human

Gene:

Neuroblastoma tumour suppressor locus

Chromosome:

01

Location:

1p36.3

Description:

Two distinct regions of somatic 1p36 loss of heterozygosity have been found in neuroblastomas (NBs) (Caron H et al, 1995). Deletions at 1p36 in NBs without MYCN amplification occur at 1p36.3 and evidence from 24 NBs suggests the maternal allele is preferentially deleted (21 maternal : 3 paternal) (Caron H et al, 2001 ). However there is conflicting evidence from 29 NBs that showed no parent of origin bias in deletions of this region (13 maternal : 16 paternal) (Hogarty MD et al., 2002 ). Larger deletions at 1p36.1 (extending to telomere) are observed in tumours with MYCN amplification, but no parent of origin effect has been observed (Hogarty MD et al, 2001).

Category:

Other

Record:

228

Last Modified 19/08/2003

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