Taxon:

Mouse

Gene:

Nap1l4 (Nap2)

Chromosome:

07

Location:

69.55 cM, distal

Description:

Nap1l4 (Nap2) shows preferential expression of the maternal allele, mainly in the placenta (Engemann S et al, 2000).
Previously, the same group (Paulsen M et al, 1998) had reported biallelic expression in multiple fetal and adult tissues.
Umlauf D et al (2004) imply that their results confirm paternal repression in the placenta but the results as shown in Figure 1 are unconvincing.
However, Okae H et al, (2012) provided strong evidence of negligible expression of Nap1l4 by qPCR and whole transcriptome sequencing in E 13.5 placentas. They suggest that this gene is not imprinted. This is concordant with Proudhon and Bourc'his, (2010) caution that maternal contamination of placental tissues may cause apparent imprinted maternal expression.

Category:

Other

Record:

225

Last Modified 1/18/2012

Links:

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