Taxon:

Mouse

Gene:

Osbpl5 (Obph1)

Chromosome:

07

Location:

69.59 cM, distal

Description:

Osbpl5 (Oxysterol binding protein-like 5, Obph1) lies outside of an imprinted region found in both mouse and human extending from Ipl/IP1 to H19, a region associated with Beckwith-Weidemann syndrome in humans. Obph1 shows predominant maternal expression in the placenta but biallelic expression in fetal and newborn organs (Engemann S, et al. 2000; Clark L et al, 2002). Analysis of a CpG island 5 to Obph1 (and more distant from the imprinted cluster) was shown to be hypo- and not differentially methylated. These results suggest that the Ip1/IPl to H19 imprinted region extends to Obph1 but that the CpG island 5 to Obph1 is not involved. Identical results were achieved in human samples (Higashimoto K, et al. 2002).
However, Okae H et al, (2012) provided strong evidence of negligible expression of Osbpl5 by qPCR and whole transcriptome sequencing in E 13.5 placentas. They suggest that this gene is not imprinted. This is concordant with Proudhon and Bourc'his, (2010) caution that maternal contamination of placental tissues may cause apparent imprinted maternal expression.

Category:

Other

Record:

224

Last Modified 1/18/2012

Links:

Gene  


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