Taxon:

Human

Gene:

NNAT (Neuronatin)

Chromosome:

20

Location:

20q11.2-q12

Description:

NNAT (Neuronatin) is transcribed specifically from the paternal allele in fetal brain (the only tissue from which expression could be detected). A 1.8-kb CpG island in its promoter region exhibits differential maternal methylation in all tissues examined (Evans HK et al, 2001). NNAT is also the first identified eutherian-specific imprinted gene(Evans HK et al, 2005).
NNAT, a three exon gene, is located within the first intron of BLCAP which is imprinted and preferentially maternally expressed in human and mouse brain (Schulz R et al, 2009). Previously BLCAP was reported to be not imprinted in fetal tissues (Evans HK et al, 2001). NNAT is transcribed antisense with respect to BLCAP.

Category:

Imprinted genes

Record:

193

Last Modified 2/4/2013

Links:

Gene  


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