Taxon:

Mouse

Gene:

Magel2

Chromosome:

07

Location:

28.0 cM

Description:

Magel2 (melanoma antigen-like gene 2, a member of the MAGE gene superfamily) is expressed exclusively from the paternal allele in adult brain (Boccaccio I et al, 1999; Lee S et al, 2000).
Some of the phenotypic features of Magel2 knockout mice resemble Prader-Willi syndrome features (neonatal growth retardation, excessive weight gain after weaning, and increased adiposity with altered metabolism in adulthood) (Bischof JM et al, 2007).
Wang X et al, (2011) provided evidence for imprinted paternal expression of Magel2 in E17.5 placenta.

Category:

Imprinted genes

Record:

190

Last Modified 2/4/2013

Links:

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