Taxon:

Human

Gene:

MAGEL2 (NDNL1)

Chromosome:

15

Location:

15q11-q13 (02)

Description:

MAGEL2 (a member of the MAGE gene superfamily) is expressed exclusively from the paternal allele in adult brain and fibroblasts (Boccaccio I et al, 1999; Lee S et al, 2000).
Some of the phenotypic features of Magel2 knockout mice resemble Prader-Willi syndrome features (neonatal growth retardation, excessive weight gain after weaning, and increased adiposity with altered metabolism in adulthood) (Bischof JM et al, 2007).
Baran Y et al (2015) found evidence of imprinting of MAGEL2 (using RNA-seq) in adult brain and pituitary tissues.

Category:

Imprinted genes

Record:

189

Last Modified 8/3/2017

Links:

Gene  


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