MAGEL2 (a member of the MAGE gene superfamily) is expressed exclusively from the paternal allele in
adult brain and fibroblasts (Boccaccio
I et al, 1999; Lee
S et al, 2000).
Some of the phenotypic features of Magel2 knockout mice resemble Prader-Willi syndrome features
(neonatal growth retardation, excessive weight gain after weaning, and increased adiposity with
altered metabolism in adulthood) (Bischof
JM et al, 2007).
Baran Y et al (2015) found evidence of imprinting
of MAGEL2 (using RNA-seq) in adult brain and pituitary tissues.