Taxon:

Human

Gene:

HLA class II genes and diabetes type I

Chromosome:

06

Location:

6p21.3

Description:

In type 1 diabetes, parental effects have been observed with respect to the inheritance of HLA class II alleles, for example an excess of maternal DR3 and paternal DR4 alleles (see each publication for details) (Deschamps I et al, 1990, Jos J et al, 1991, Margaritte-Jeannin P et al, 1995, Feugeas JP et al, 1996, Noble JA et al, 1996). Others dispute the occurrence of parental effects on the inheritance of HLA-encoded susceptibility (Bain SC et al, 1994, Undlien DE et al, 1995).

Category:

Parental effect

Record:

170

Last Modified 4/27/2010

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