Taxon:

Pig

Gene:

IGF2 and a linked QTL for lean meat

Chromosome:

02

Location:

2p1.7

Description:

IGF2 is paternally expressed in fetal liver and muscle, and in piglet heart, liver, brain, lung, kidney, stomach, pancreas, thymus, tongue, muscle, bladder, spleen and placenta. The IGF2 P1 transcript is bi-allelically expressed (not imprinted) in all major organs studied (Nezer C, et al. 1999; Li C, 2008). IGF2 DMRs have been reported (Han DW, 2008). Bischoff SR et al, 2009 showed paternal expression of the P2, P3 and P4 transcripts in pig placenta, but failed to detect P1 transcript expression in any of the tissues examined.

A quantitative trait locus (QTL) with postnatal effects on the lean meat content in ham, longissimus muscle area, backfat thickness and heart weight is linked to pig IGF2 and is paternally inherited (Jeon JT, et al 1999;  Nezer C, et al. 1999; Nezer C et al, 2003; Jungerius BJ et al, 2004).
The QTL is caused by a nucleotide substitution in intron 3 of IGF2. The mutation does not seem to affect the imprinting status of the allele, but it increases the expression of IGF2 from promoters P2-P4 3-fold in postnatal skeletal muscle when homozygous or paternally inherited. The mutation was shown to reduce interaction with some nuclear factor, possibly a repressor, which could explain the increase in expression of IGF2 with this QTL (Van Laere AS, et al. 2003).

Category:

Imprinted genes

Record:

166

Last Modified 6/29/2010

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