Taxon:

Sheep

Gene:

IGF2

Chromosome:

21

Location:

21q21-qter

Description:

IGF2 is paternally expressed in sheep, but biallelic in adult sheep liver (as seen in humans)(McLaren RJ et al, 1999). Additional evidence for imprinting was provided by underexpression in sheep gynogenetic allantoic and trophoblastic tissue (Hagemann LJ et al, 1998).
Upstream of H19, methylation was exclusively on the paternal allele consistent with paternal expression of IGF2 (Young LE A et al 2003).
IGF2 expression levels in parthenogenetic 21 day fetuses was 0.04 times that of control fetuses, consistent with paternal expression. In parthenogenetic chorioallantois it was 0.07-fold that of controls (Thurston A et al 2008).

Category:

Imprinted genes

Record:

163

Last Modified 1/4/2008

Links:

Gene  


*To look at further records use the Back button on your browser to return to the Summary Table

New Search

Home