Taxon:

Human

Gene:

DIRAS3 (ARHI, NOEY2) (Provisional data)

Chromosome:

01

Location:

1p31

Description:

DIRAS3 (DIRAS family, GTP-binding RAS-like 3, ARHI, NOEY2) is a ras-related gene which acts as a growth regulator in ovarian and breast cancers (Yuan J, et al 2003).
It is reported to be paternally expressed and maternally 'imprinted' (Yu Y et al 1999). However the data are minimal. Monoallelic expression was detected in 4/4 informative samples which included two cancer cell lines, one ovarian surface epithelium primary culture and one normal breast epithelium sample. In the last sample only, the expressed allele could be identified and was paternal. In three families, using an intron 1 (AT)n polymorphism, only the maternal DNA allele could be amplified in all six offspring after genomic DNA was digested by the methylation-sensitive restriction enzyme BstUI. In another family, only the maternal allele at position -750 bp could be amplified after BstUI digestion.
Methylation sensitive Southern blotting showed evidence of partial methylation in the promoter CpG island in normal tissues (Luo RZ et al 2001).
It has three CpG islands.

Category:

Imprinted genes

Record:

161

Last Modified 1/27/2016

Links:

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