Taxon:

Human

Gene:

ZNF215 (provisional evidence)

Chromosome:

11

Location:

11p15.4

Description:

ZNF215 is a zinc finger gene 3.9 Mb centromeric of OSBPL5 the most centromeric of the imprinted genes in the KCNQ1 imprinting cluster on 11p15.5. It has five alternatively spliced isoforms, two of which were preferentially expressed from the maternal allele in tissues from two fetuses (SSCP analysis of nested RT-PCR products) (Alders M et al, 2000).
Extract from paper: "The maternal allele of ZNF215V1 is preferentially expressed in liver, lung, kidney, and testis but also that, in the brain and heart, these alleles are nearly equally expressed. Interestingly, ZNF215V3 also is partially imprinted in lung, liver, and kidney but is completely imprinted in heart. In brain tissue, however, complete imprinting is seen in fetus 2, whereas, in fetus 1, both alleles are expressed indicating either that, at least in this tissue, individual variation exists or that imprinting may vary in different stages of development"
However, Morcos L et al, (2011) found no evidence of allelic expression bias in lymphoblast and fibroblast cell lines.

Category:

Imprinted genes

Record:

153

Last Modified 7/15/2012

Links:

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