Taxon:

Human

Gene:

TP73 (conflicting evidence)

Chromosome:

01

Location:

1p36.33

Description:

TP73 (tumour protein p73) was reported to be maternally expressed in blood and some neuroblastoma cell lines (Kaghad M et al, 1997). Maternal expression has been confirmed in fetal pancreas and thymus and in adult normal kidney and oesophagus (Mai M et al, 1998; Cai YC et al, 2000). Monoallelic expression was confirmed in peripheral blood (Martinez-Delgado et al, 2002) and in 3 of 4 fetal brains, but biallelic expression was observed in all other fetal tissues (Hu JF et al, 2000). No imprinting of TP73 was found in 27 of 29 lung specimens and in one case with allelic imbalance the preferentially expressed allele was paternally derived (Nomoto S et al, 1998). Variable imprinting was found in human placenta (Diplas AI et al, 2009).
Biallelic expression of TP73 was found in 8 or 8 human embryonic stem cell lines (Kim KP et al, 2007).
TP73 is located in the region showing preferential maternal loss of heterozygosity in neuroblastomas without MYCN amplification (Caron H et al, 1995), but some have argued against a role in neuroblastoma (Ejeskar K et al, 1999). TP73 is a candidate tumour suppressor gene involved in lymphoma (Martinez-Delgado et al, 2002).
Morcos L et al, (2011) found no evidence of allelic expression bias in lymphoblast and fibroblast cell lines.

Category:

Imprinted genes

Record:

4

Last Modified 7/15/2012

Links:

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