Taxon:

Human

Gene:

ASCL2 (HASH2)

Chromosome:

11

Location:

11p15.5 (04)

Description:

There is mixed evidence regarding ASCL2 (Achaete Scute complex like 2, the human homologue of imprinted murine Mash2, a helix-loop-helix transcription factor).
Biallelic expression was detected in early placental tissue by using allele-specific RT-PCR (Westerman BA, 2001) and further studies of 16 placental samples (weeks 12-39 of gestation) all showed biallelic expression suggesting that human ASCL2 escapes imprinting (Miyamoto T et al. 2002).
Previously, lack of expression in hydatidiform moles suggested imprinting of ASCL2 in humans (Alders M et al, 1997).
Overall there is insufficient evidence to conclude that human ASCL2 is imprinted.

Category:

Other

Record:

28

Last Modified 4/3/2008

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