There is mixed evidence regarding ASCL2 (Achaete Scute complex like 2, the human homologue of
imprinted murine Mash2, a helix-loop-helix transcription factor).
Biallelic expression was detected in early
placental tissue by using allele-specific RT-PCR (Westerman
BA, 2001) and further studies of 16 placental samples (weeks 12-39 of gestation) all showed
biallelic expression suggesting that human ASCL2 escapes imprinting (Miyamoto
T et al. 2002).
Previously, lack of expression in
hydatidiform moles suggested imprinting of ASCL2 in humans (Alders
M et al, 1997).
Overall there is insufficient evidence to conclude that human ASCL2 is imprinted.