IGF2 (Insulin-like growth factor 2, a fetal growth factor) is paternally expressed in nearly all
human tissues. Expression is not imprinted in the choroid plexus, leptomeninges, brain, bone marrow,
human liver and chondrocytes. Its imprinting is under the control of enhancers upstream of the H19
S, 1993; Ogawa
O, 1993; Ohlsson
R, 1993). Analysis of imprinting of IGF2 in peripheral blood suggest imprinting maybe
polymorphic, with biallelic expression being observed in ~10% of individuals (4 of 38 in japanese
T et al 2001).
IGF2 has two secondary (post-fertilisation) DMRs. DMR0 is in intron 2, and shows maternal
M et al, 1999). DMR2 overlaps intron 8 and exon 9 and shows maternal methylation (demonstrated
at 2 HpaII sites) in human blood (Reik
W et al, 1994; Reik
W et al, 1995).