Taxon:

Human

Gene:

H19, miR-675

Chromosome:

11

Location:

11p15.5 (01)

Description:

H19 is maternally expressed in humans and mouse. The gene product is an abundant untranslated RNA. An imprint-control region (ICR) 2-4.4 kb upstream of H19 controls the imprinting of IGF2. The unmethylated maternal allele has binding sites for CTCF that prevents access of the enhancers to IGF2 (Rachmilewitz J, et al 1992; Rainier S et al, 1993; Zhang Y et al, 1992; Frevel M et al, 1999 [for DMR boundaries]).
H19 is host to miR-675, a 23-nucleotide microRNA derived from nucleotides 1014 1036 of the H19 RNA transcript (Cai X & Cullen BR, 2007).

Category:

Imprinted genes

Record:

25

Last Modified 12/5/2007

Links:

Gene  


*To look at further records use the Back button on your browser to return to the Summary Table

New Search

Home