Taxon:

Mouse

Gene:

Gct4, Gct6

Chromosome:

X

Location:

36 cM

Description:

An X-linked modifier from the mouse strain SJL increases susceptibillity to juvenile-type granulosa cell tumors in a SWR strain background. This effect is observed only when this region is inherited paternally (Beamer WG et al 1998). SJL/SWR crosses mapped the effect to a 3 cM region on X (36 cM) designated "Gct4", including the Ar gene. Further mapping was carried out using a second congenic mouse strain (SWR.CAST-X), containing most of the more polymorphic X chromosome from mouse strain CAST/Ei. This revealed a second SJL modifier region designated Gct6, 6.5cM distal to Gct4 (Dorward AM et al 2003).

Category:

Parental effect

Record:

112

Last Modified 27/06/2005

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