The detailed entries of the Imprinted Gene Catalogue database were created by Benjamin Tycko, Columbia University, New York and are updated by Ian Morison


 

Detailed entry for Gene:

Slc22a1l
SLC22A1LS
Impt1, Orctl2, Tssc5
Itm, BWR1A

Chromosome:

Human Chr11p15.5
Mouse Chr7 (distal)

Links:

OMIM

Imprinting:

The paternal allele of Slc22a1l is repressed; maternal allele active, with the strongest imprint in the extraembryonic tissues (placenta and yolk sac of mice and placenta and amnion of humans) (Cooper PR et al, 1998; Dao D et al, 1998; Dao D et al, 1999). Weaker and more variable imprinting is observed in fetal tissues, but some show a strong allelic expression bias (Cooper PR et al, 1998; Dao D et al, 1998; Dao D et al, 1999). There is often biallelic expression in adult tissues (Dao D et al, 1998; Sakatani T et al, 2001) .

Gene Product:

Slc22a1l encodes a membrane transport protein in the major facilitator superfamily (Dao D et al, 1998).

Functional Data:

The major facilitator gene family is a large one, including genes that code for transporters of organic cations, organic anions, sugars, and various drugs (Saier MH, Jr. et al, 1999). The Slc22a1l gene is highly expressed in transporting organs, such as kidney, liver, placenta and yolk sac, but its transport substrates are not yet known. The protein encoded by Slc22a1l can promote chloroquine and quinidine transport in transfected bacterial cells, so the substrates in mammalian cells may be organic cations (Reece M et al, 1998).

 

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