The detailed entries of the Imprinted Gene Catalogue database were created by Benjamin Tycko, Columbia University, New York and are updated by Ian Morison


 

Detailed entry for Gene:

Obph1
(OSBPL5)

Chromosome:

Human Chr11p15.5
Mouse Chr7 (distal)

Links:

OMIM

Imprinting:

In mouse the paternal allele of Obph1 is repressed; maternal allele predominantly expressed, but only in placenta: all other organs showed biallelic expression (Engemann S et al, 2000). This justifies a provisional claim of functional imprinting; pending exclusion of high expression by the maternal decidua. Obph1 is expressed biallelically in other tissues. No human data available.

Gene Product:

The protein encoded by Obph1 has similarity to oxysterol binding proteins.

Functional Data:

In general, oxysterol-binding proteins, encoded by a gene family that contains at least 12 members in humans, function in regulating sterol biosynthesis and transport. Consistent with a function in intracellular trafficking, many of these proteins, including Obph1/ORP5, contain pleckstrin-homology domains, that can mediate association with membranes in the golgi apparatus, and possibly elsewhere in the cell (Lehto M et al, 2001).

 

Click here to search again.

Return to the Imprinted Gene Catalogue home page.