The detailed entries of the Imprinted Gene Catalogue database were created by Benjamin Tycko, Columbia University, New York and are updated by Ian Morison


 

Detailed entry for Gene:

Ascl2
Mash2
HASH2

Chromosome:

Human Chr11p15.5
Mouse Chr7 (distal)

Links:

OMIM

Imprinting:

The paternal allele of Ascl2 is silenced; maternal allele active in mice and, probably, in humans (expression absent from androgenetic hydatidiform moles) (Alders M et al, 1997; Caspary T et al, 1998; Guillemot F et al, 1995; Tanaka M et al, 1999). Expression and functional imprinting of Ascl2 is only observed in placenta (Guillemot F et al, 1995; Guillemot F et al, 1994).

Gene Product:

Transcription factor; basic helix-loop-helix (bHLH) family (Janatpour MJ et al, 1999).

Functional Data:

In the placenta, Ascl2 acts in a cell-autonomous manner to inhibit the differentiation of proliferating spongiotrophoblast into giant cells (Guillemot F et al, 1994; Tanaka M et al, 1997). Placentas of Ascl2-knockout mice have a relative increase in giant cells and a deficiency of spongiotrophoblast, and the conceptuses fail at mid-gestation (Guillemot F et al, 1994; Tanaka M et al, 1997).

 

Click here to search again.

Return to the Imprinted Gene Catalogue home page.