The detailed entries of the Imprinted Gene Catalogue database were created by Benjamin Tycko, Columbia University, New York and are updated by Ian Morison


 

Detailed entry for Gene:

Ipw

Chromosome:

Human Chr15q11-q12
Mouse Chr7 (central)

Links:

OMIM

Imprinting:

The maternal allele of Ipw is silenced; paternal allele active in mice and humans (Yang T et al, 1998; Wevrick R et al, 1997; Wevrick R et al, 1996; Wevrick R et al, 1994).

Gene Product:

Ipw (Imprinted in Prader-Willi syndrome) encodes an abundant, spliced and polyadenylated RNA, which lacks conserved open reading frames . Ipw RNA accumulates in the cytoplasm, and shows high expression in brain, as well as other tissues. The IPW transcript comprises exons 59-61 of is the extended SNURF-SNRPN transcript (Runte et al, 2001; Wevrick R et al, 1994). There is evolutionary conservation of its gene structure in mammals (Wevrick R et al, 1997; Wevrick R et al, 1996; Wevrick R et al, 1994)

Functional Data:

Mutant mice with a deletion encompassing Ipw appear normal (Johnson DK et al, 1995). As predicted from the localization of Ipw to the major Prader-Willi syndrome deletion, and its direction of imprinting, Ipw RNA is absent from PWS tissues and from tissues of a mouse model for PWS (Yang T et al, 1998; Wevrick R et al, 1996; Wevrick R et al, 1994).

 

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