The detailed entries of the Imprinted Gene Catalogue database were created by Benjamin Tycko, Columbia University, New York and are updated by Ian Morison


Detailed entry for Gene:



Human Chr
Mouse Chr18


Maternal allele silenced in mouse tissues, but IMPACT is not imprinted in humans (Hagiwara Y et al, 1997; Okamura K et al, 2000).

Gene Product:

Conserved protein; no clear functional motifs (Yamada Y et al, 1999).

Functional Data:

Overexpression of the frog (Xenopus) homologue Impact (which is biallelically expressed) by RNA microinjection resulted in a higher than normal rate of gastrulation defects (Yamada Y et al, 1999).


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