Description: MEG3 (GTL2, maternally expressed gene 3) is maternally expressed (Miyoshi N et al, 2000). It encodes a
nontranslated RNA. MEG3 and the adjacent gene DLK1 are reciprocally imprinted and the regions
shows structural similarities to IGF2/H19 (Wylie AA et al, 2000).
There is paternal specific methylation upstream of MEG3 in a region that contains multiple CTCF
binding sites (Rosa AL et al, 2005).
The location of the human equivalent of the mouse IG-DMR is not clear. Two DMRs have been located
upstream of MEG3, referred to as CpG1 and CpG2, 15 kb and 1.7 kb upstream of MEG3 respectively (Kawakami
T et al, 2006).
IK et al (2007) refer to methylation studies in the IG-DMR but their reported sequence is from
the MEG3 promoter DMR.
Baran Y et al (2015) found evidence of imprinting
of MEG3 (using RNA-seq) in multiple adult tissues (subcutaneous adipose, visceral adipose, adrenal gland, aorta,
coronary artery, tibial artery, brain, mammary tissue, transverse colon, oesophagus mucosa, oesophagus muscularis,
transformed fibroblasts, atrial appendage, left ventricle, liver, lung, skeletal muscle, tibial nerve, ovary, pancreas,
prostate, pituitary, not sun exposed skin, sun exposed skin, stomach, testis, thyroid, uterus, vagina and whole blood).