Description: RT-PCR studies using human lymphocytes and the SNP analysis in the human placenta revealed that the
human ZDBF2 (zinc finger, DBF-type containing 2) is paternally expressed in lymphocytes but
biallelically expressed in
the placenta. The placenta-specific escape from imprinting is
similar to that observed in the imprinted mouse Zdbf2 gene (Kobayashi,
H. et al, 2009).
Morcos L et al (2011) showed
strongly biased paternal expression of ZDBF2 in human lymphoblast cell lines from nine informative
Baran Y et al (2015) found evidence of imprinting
of ZDBF2 (using RNA-seq) in multiple adult tissues (subcutaneous adipose, visceral adipose, adrenal gland, aorta,
tibial artery, brain, mammary tissue, oesophagus muscularis, transformed fibroblasts, atrial appendage, left ventricle,
EBV-transformed lymphocytes, lung, skeletal muscle, tibial nerve, ovary, prostate, pituitary, stomach, thyroid). No
evidence of imprinting was seen in pancreas and testis tissues.